GAD1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GAD1.
Immunogen
A synthetic peptide corresponding to internal region of human GAD1.
Sequence
QRTNSLEEKSR
Host
Goat
Theoretical MW (kDa)
70
Reactivity
Chicken, Dog, Human, Mouse, Pig, Rat
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (1-3ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GAD1 polycolnal antibody (Cat # PAB27574) (1ug/ml) staining of mouse brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. -
Gene Info — GAD1
Entrez GeneID
2571Protein Accession#
NP_038473.2;NP_000808.2Gene Name
GAD1
Gene Alias
FLJ45882, GAD, SCP
Gene Description
glutamate decarboxylase 1 (brain, 67kDa)
Gene Ontology
HyperlinkGene Summary
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq
Other Designations
OTTHUMP00000041055|glutamate decarboxylase 1|glutamate decarboxylase 1 (brain, 67kD)
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Interactome
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Pathway
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Disease
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