BCL2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of BCL2 in A-20 cell lysates with BCL2 polyclonal antibody (Cat # PAB13119) at (A) 1, (B) 2, and (C) 4 ug/mL .
Immunocytochemistry
Immunocytochemistry of BCL2 in A-20 cells with BCL2 polyclonal antibody (Cat # PAB13119) at 2 ug/mL .
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCL2.
Immunogen
A synthetic peptide corresponding to internal region 14 amino acids of human BCL2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BCL2 in A-20 cell lysates with BCL2 polyclonal antibody (Cat # PAB13119) at (A) 1, (B) 2, and (C) 4 ug/mL .Immunocytochemistry
Immunocytochemistry of BCL2 in A-20 cells with BCL2 polyclonal antibody (Cat # PAB13119) at 2 ug/mL . -
Gene Info — BCL2
Entrez GeneID
596Protein Accession#
AAH27258Gene Name
BCL2
Gene Alias
Bcl-2
Gene Description
B-cell CLL/lymphoma 2
Omim ID
151430Gene Ontology
HyperlinkGene Summary
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq
Other Designations
B-cell lymphoma protein 2|OTTHUMP00000163680
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Interactomes
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Pathways
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Diseases
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Publication Reference
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The Bcl-2 protein family and its role in the development of neoplastic disease.
Heiser D, Labi V, Erlacher M, Villunger A.
Experimental Gerontology 2004 Aug; 39(8):1125.
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The Bcl-2 family: roles in cell survival and oncogenesis.
Cory S, Huang DC, Adams JM.
Oncogene 2003 Nov; 22(53):8590.
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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.
Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ.
Nature 1990 Nov; 348(6299):334.
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The Bcl-2 protein family and its role in the development of neoplastic disease.
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