CYLD polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYLD.
Immunogen
A synthetic peptide corresponding to amino acids 500-600 of human CYLD.
Host
Rabbit
Reactivity
Bovine, Human, Mouse, Primates
Form
Liquid
Recommend Usage
Western Blot (2 mg/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CYLD in Jurkat whole cell extract using CYLD polyclonal antibody (Cat # PAB12454). -
Gene Info — CYLD
Entrez GeneID
1540Protein Accession#
Q9NQC7Gene Name
CYLD
Gene Alias
CDMT, CYLD1, CYLDI, EAC, FLJ20180, FLJ31664, FLJ78684, HSPC057, KIAA0849, MFT, MFT1, SBS, TEM, USPL2
Gene Description
cylindromatosis (turban tumor syndrome)
Gene Ontology
HyperlinkGene Summary
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
deubiquitinating enzyme CYLD|ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin specific peptidase like 2|ubiquitin thiolesterase CYLD|ubiquitin-specific-processing protease CYLD
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Interactome
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Disease
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Publication Reference
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Reduced expression of CYLD in human colon and hepatocellular carcinomas.
Hellerbrand C, Bumes E, Bataille F, Dietmaier W, Massoumi R, Bosserhoff AK.
Carcinogenesis 2007 Jan; 28(1):21.
Application:WB, IHC-P, Human, Human colon, Hepatocellular carcinomas, HepG2, PLC cells.
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Reduced expression of CYLD in human colon and hepatocellular carcinomas.
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