FOXP3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FOXP3.
Immunogen
A synthetic peptide corresponding to smino acids 400-431 of human FOXP3.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to human FOXP3.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000-1:5000)
Immunohistochemistry (Frozen sections) (1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0
Storage Instruction
Store at 4°C. Do not freeze.
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Applications
Western Blot
Western blot analysis of human FOXP3 using FOXP3 polyclonal antibody (Cat # PAB12426). Lane 1 : Human CD4+CD25+ PBL, lane 2 : HEK293T transfected with human Foxp3 cDNA, lane 3 : 293/mouse foxp3, lane 4 : 293/empty vector.Immunohistochemistry (Frozen sections)
Immunohistochemistry
Staining of FOXP3 on Healthy thymus from a C57BL/6 mouse using FOXP3 polyclonal antibody (Cat # PAB12426). -
Gene Info — FOXP3
Entrez GeneID
50943Protein Accession#
Q9BZS1Gene Name
FOXP3
Gene Alias
AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID
Gene Description
forkhead box P3
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000025832|immune dysregulation, polyendocrinopathy, enteropathy, X-linked|immunodeficiency, polyendocrinopathy, enteropathy, X-linked|scurfin
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Interactome
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Disease
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Publication Reference
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Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta.
Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P, Ray A.
The Journal of Clinical Investigation 2006 Apr; 116(4):996.
Application:Flow Cyt, WB, Mouse, Mouse T cells.
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Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells.
Ochando JC, Yopp AC, Yang Y, Garin A, Li Y, Boros P, Llodra J, Ding Y, Lira SA, Krieger NR, Bromberg JS.
The Journal of Immunology 2005 Jun; 174(11):6993.
Application:IF, Mouse, LN, Spleen.
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Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment.
Polanczyk MJ, Carson BD, Subramanian S, Afentoulis M, Vandenbark AA, Ziegler SF, Offner H.
Journal of Immunology 2004 Aug; 173(4):2227.
Application:WB-Tr, Human, HEK 293T cells.
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Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta.
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