RTN4R (Human) Recombinant Protein
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Specification
Product Description
Human RTN4R (Q9BZR6, Cys27-Ser447) partial recombinant protein with His tag at C-Terminus expressed in HEK293 cells.
Sequence
Cys27-Ser447
Host
Human
Theoretical MW (kDa)
46.4
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
The EC50 was 15.8 ng/mL, messured by ELISA at 2 ug/mL.
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human NOGOR is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human NOGOR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human NOGOR, His Tag at 2 ug/mL (100 uL/Well) on the plate. Dose response curve for Anti-NOGOR Antibody, hFc Tag with the EC50 of 15.8 ng/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — RTN4R
Entrez GeneID
65078Protein Accession#
Q9BZR6Gene Name
RTN4R
Gene Alias
NGR, NOGOR
Gene Description
reticulon 4 receptor
Gene Ontology
HyperlinkGene Summary
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq
Other Designations
Nogo-66 receptor|UNQ330/PRO526|nogo receptor
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