CCR2 (Human) Recombinant Protein
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Enzyme-linked Immunoabsorbent Assay
Immobilized Human CCR2b VLP at 5 ug/mL (100 uL/Well) on the plate. Dose response curve for Anti-CCR2b Antibody, hFc Tag with the EC50 of 12.0 ng/mL determined by ELISA.
SEC-HPLC
he purity of Human CCR2b VLP is greater than 95% as determined by SEC-HPLC.
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Specification
Product Description
Human CCR2 (P41597-2, Met1-Leu360) partial recombinant protein expressed in HEK293 cells.
Sequence
Met1-Ala374
Host
Human
Theoretical MW (kDa)
42.9
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
The EC50 was 12.0 ng/mL, messured by ELISA at 5 ug/mL.
Isotype
CCR2 (Human) Recombinant Protein
Quality Control Testing
SEC-HPLC
SEC-HPLC
he purity of Human CCR2b VLP is greater than 95% as determined by SEC-HPLC.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human CCR2b VLP at 5 ug/mL (100 uL/Well) on the plate. Dose response curve for Anti-CCR2b Antibody, hFc Tag with the EC50 of 12.0 ng/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — CCR2
Entrez GeneID
729230Protein Accession#
P41597-2Gene Name
CCR2
Gene Alias
MGC168006
Gene Description
chemokine (C-C motif) receptor 2-like
Gene Ontology
HyperlinkGene Summary
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq
Other Designations
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Pathway
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Disease
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