DSG2 (Human) Recombinant Protein
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More Files
- More Functions
Enzyme-linked Immunoabsorbent Assay
Immobilized Human DSG-2, His Tag at 0.5 ug/mL (100 uL/well) on the plate. Dose response curve for Anti-DSG-2 Antibody, hFc Tag with the EC50 of 10.7 ng/mL determined by ELISA.
SEC-HPLC
The purity of Human DSG-2 is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human DSG-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human DSG2 (Q14126, Ala50-Gly609) partial recombinant protein with His tag at C-Terminus expressed in HEK293 cells.
Sequence
Ala50-Gly609
Host
Human
Theoretical MW (kDa)
63.6
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE; > 90% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
The EC50 was 10.7 ng/mL, messured by ELISA at 0.5 ug/mL.
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human DSG-2 is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human DSG-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human DSG-2, His Tag at 0.5 ug/mL (100 uL/well) on the plate. Dose response curve for Anti-DSG-2 Antibody, hFc Tag with the EC50 of 10.7 ng/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — DSG2
Entrez GeneID
1829Protein Accession#
Q14126Gene Name
DSG2
Gene Alias
ARVC10, ARVD10, CDHF5, HDGC, MGC117034, MGC117036, MGC117037
Gene Description
desmoglein 2
Gene Ontology
HyperlinkGene Summary
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq
Other Designations
HDGC
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Interactome
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Pathway
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Disease
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