CCL21 (Human) Recombinant Protein
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Specification
Product Description
Human CCL21 (O00585, 1 a.a. - 134 a.a.) full-length recombinant protein. expressed in Escherichia coli.
Sequence
MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP
Host
Escherichia coli
Theoretical MW (kDa)
12
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ion exchange column and HPLC reverse phase column
Purity
> 90% by SDS-PAGE and HPLC
Endotoxin Level
< 0.1 ng/ug (1 EU/ug)
Activity
Determined by the ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/mL.
Storage Buffer
Lyophilized from 2.5% glycine, 0.5% sucrose, 0.01% Tween 80, 5 mM Glutamic acid, pH 4.5
Storage Instruction
Store at -20°C on dry atmosphere for 2 years.
After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — CCL21
Entrez GeneID
6366Protein Accession#
O00585Gene Name
CCL21
Gene Alias
6Ckine, CKb9, ECL, MGC34555, SCYA21, SLC, TCA4
Gene Description
chemokine (C-C motif) ligand 21
Omim ID
602737Gene Ontology
HyperlinkGene Summary
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq
Other Designations
Efficient Chemoattractant for Lymphocytes|OTTHUMP00000000526|OTTHUMP00000000527|OTTHUMP00000021304|beta chemokine exodus-2|exodus-2|secondary lymphoid tissue chemokine|small inducible cytokine A21|small inducible cytokine subfamily A (Cys-Cys), member 21
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