FKBP2 (Human) Recombinant Protein
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Specification
Product Description
Human FKBP2 (NP_001128680, 22 a.a. - 142 a.a.) partial recombinant protein expressed in Escherichia coli.
Sequence
MATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATLVFEVELLKIERRTEL
Host
Escherichia coli
Theoretical MW (kDa)
13.4
Form
Liquid
Preparation Method
Escherichia coli expression system
Purification
Conventional Chromatography
Concentration
1 mg/mL
Purity
> 90% by SDS-PAGE
Activity
Specific activity is > 270 nmoles/min/ug, and is defined as the amount of enzyme that cleaves 1umole of suc-AAPF-pNA per minute at 25°C in Tris-HCl pH 8.0 using chymotrypsin.
Quality Control Testing
Loading 3 ug protein in 15% SDS-PAGE
Storage Buffer
In 20 mM Tris buffer, pH 8.0 (10% glycerol, 1 mM DTT).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — FKBP2
Entrez GeneID
2286Protein Accession#
NP_001128680Gene Name
FKBP2
Gene Alias
FKBP-13, PPIase
Gene Description
FK506 binding protein 2, 13kDa
Omim ID
186946Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
FK506 binding protein 2 (13kD)|FK506-binding protein 2 (13kD)|peptidyl-prolyl cis-trans isomerase|proline isomerase|rapamycin-binding protein
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Interactome
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