MMP9 monoclonal antibody, clone SB15c (HRP)
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Paraffin embedded sections of human colon were stained with MMP9 monoclonal antibody, clone SB15c. Goat Anti-Mouse IgG2a, human ads-BIOT and Streptavidin-HRP were used and then developed with DAB.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant MMP9.
Immunogen
Recombinant protein corresponding to human MMP9.
Host
Mouse
Reactivity
Human
Specificity
human MMP-9; Does not cross react to human MMP-1, MMP-2 or MMP-3.
Form
Liquid
Conjugation
HRP
Isotype
IgG2a
Recommend Usage
ELISA (1:1000-1:4000)
Immunohistochemistry (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Paraffin embedded sections of human colon were stained with MMP9 monoclonal antibody, clone SB15c. Goat Anti-Mouse IgG2a, human ads-BIOT and Streptavidin-HRP were used and then developed with DAB.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP9
Entrez GeneID
4318Gene Name
MMP9
Gene Alias
CLG4B, GELB, MMP-9
Gene Description
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Omim ID
120361Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq
Other Designations
92kD type IV collagenase|OTTHUMP00000031674|gelatinase B|macrophage gelatinase|matrix metalloproteinase 9|matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase)|matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kD
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Interactome
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Pathway
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Disease
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Publication Reference
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Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity.
Lelongt B, Bengatta S, Delauche M, Lund LR, Werb Z, Ronco PM.
The Journal of Experimental Medicine 2001 Apr; 193(7):793.
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Degradation of interleukin 1beta by matrix metalloproteinases.
Ito A, Mukaiyama A, Itoh Y, Nagase H, Thogersen IB, Enghild JJ, Sasaguri Y, Mori Y.
The Journal of Biological Chemistry 1996 Jun; 271(25):14657.
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Matrix metalloproteinases degrade myelin basic protein.
Chandler S, Coates R, Gearing A, Lury J, Wells G, Bone E.
Neuroscience Letters 1995 Dec; 201(3):223.
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Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity.
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