ITGB1 monoclonal antibody, clone DF7
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGB1.
Immunogen
Native purified human ITGB1.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with the b1 subunit of the integrin protein family. The monoclonal antibody reacts with an extracellular epitope of the b1 integrin molecule. b1 -Integrins mediate cell-extracellular matrix interactions and share a common b-subunit. Monoclonal antibodies against this b1 -Integrin subunit are applicable in paraffin-embedded and frozen sections, immunoblotting and immunoprecipitation. Numerous studies have shown that b1 -Integrins have a distinct and wide cellular distribution and that there are alterations in malignant cells in their b1-integrin expression. Monoclonal antibody to b1 integrin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (1% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ITGB1
Entrez GeneID
3688Gene Name
ITGB1
Gene Alias
CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
Gene Description
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Omim ID
135630Gene Ontology
HyperlinkGene Summary
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000019420|OTTHUMP00000046253|OTTHUMP00000063731|OTTHUMP00000063732|OTTHUMP00000063733|fibronectin receptor beta subunit|integrin VLA-4 beta subunit|integrin beta 1
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Interactome
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