ABCC2 monoclonal antibody, clone M2II-12
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant ABCC2.
Immunogen
Recombinant fusion protein corresponding to amino acids 860-950 of human ABCC2.
Host
Mouse
Reactivity
Human
Specificity
Reacts with an internal epitope of human cMOAT/MRP2. Does not cross-react with human MDR1, MRP1, MRP3, and MRP5 gene products.
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (1:20-50)
Immunohistochemistry (Frozen sections) (1:20)
Immunocytochemistry (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum-free cell culture supernatant (0.09% sodium azide, 0.7% BSA)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunocytochemistry
Flow Cytometry
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Gene Info — ABCC2
Entrez GeneID
1244Gene Name
ABCC2
Gene Alias
ABC30, CMOAT, DJS, KIAA1010, MRP2, cMRP
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq
Other Designations
OTTHUMP00000020267|canalicular multispecific organic anion transporter
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Interactome
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