VCL monoclonal antibody, clone hVIN-1
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Specification
Product Description
Mouse monoclonal antibody raised against native VCL.
Immunogen
Native purified human uterus VCL.
Host
Mouse
Theoretical MW (kDa)
116
Reactivity
Chicken, Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Frozen section) (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
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Gene Info — VCL
Entrez GeneID
7414Gene Name
VCL
Gene Alias
CMD1W, MVCL
Gene Description
vinculin
Gene Ontology
HyperlinkGene Summary
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000019861|OTTHUMP00000043885|metavinculin
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Interactome
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Pathway
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Disease
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Publication Reference
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Complementary physical and genetic techniques map the vinculin (VCL) gene on chromosome 10q.
Mulligan LM, Gardner E, Telenius H, Ponder BA.
Genomics 1992 Aug; 13(4):1347.
Application：WB-Ce, WB-Tr, Human, Mammalian cells.
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Complete sequence of human vinculin and assignment of the gene to chromosome 10.
Weller PA, Ogryzko EP, Corben EB, Zhidkova NI, Patel B, Price GJ, Spurr NK, Koteliansky VE, Critchley DR.
PNAS 1990 Aug; 87(15):5667.
Application：WB-Ce, WB-Re, Human, Human fibroblasts, Recombinant proteins.
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Complementary physical and genetic techniques map the vinculin (VCL) gene on chromosome 10q.
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