RGS1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human RGS1 full-length ORF ( AAH15510, 1 a.a. - 196 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPRKAEEIYKAFVHLDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
47.3
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — RGS1
Entrez GeneID
5996GeneBank Accession#
BC015510Protein Accession#
AAH15510Gene Name
RGS1
Gene Alias
1R20, BL34, IER1, IR20
Gene Description
regulator of G-protein signaling 1
Omim ID
600323Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq
Other Designations
B-cell activation protein BL34|OTTHUMP00000033591|early response protein 1R20|immediate-early response 1, B-cell specific|regulator of G-protein signalling 1
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Interactome
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Disease
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