PTGER4 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PTGER4 partial ORF ( NP_000949, 379 a.a. - 488 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (81); Rat (80)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PTGER4
Entrez GeneID
5734GeneBank Accession#
NM_000958Protein Accession#
NP_000949Gene Name
PTGER4
Gene Alias
EP4, EP4R, MGC126583
Gene Description
prostaglandin E receptor 4 (subtype EP4)
Omim ID
601586Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq
Other Designations
PGE receptor, EP4 subtype|prostaglandin E receptor 4, subtype EP4|prostaglandin E2 receptor
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Interactome
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Pathway
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Disease
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