BCL2A1 (Human) Recombinant Protein (P02)
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More Files
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Specification
Product Description
Human BCL2A1 full-length ORF ( NP_004040.1, 1 a.a. - 175 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
46.5
Interspecies Antigen Sequence
Mouse (73); Rat (76)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — BCL2A1
Entrez GeneID
597GeneBank Accession#
NM_004049.2Protein Accession#
NP_004040.1Gene Name
BCL2A1
Gene Alias
ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1
Gene Description
BCL2-related protein A1
Omim ID
601056Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
hematopoietic BCL2-related protein A1
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Interactome
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Pathway
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Disease
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