PLAG1/CEN8p FISH Probe
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More Files
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
human cervix cancer (FFPE) stained with PLAG1/CEN8p FISH Probe . human cervix cancer showed no PLAG1 amplification.
Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: PLAG1
Size: Approximately 420kb
Fluorophore: Texas Red
Location: 8q12.1Probe 2
Name: CEN8p
Size: Approximately 520kb
Fluorophore: FITC
Location: 8p11.21Probe Gap
The gap between two probes is approximately 16,400 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome.
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
human cervix cancer (FFPE) stained with PLAG1/CEN8p FISH Probe . human cervix cancer showed no PLAG1 amplification. -
Gene Info — PLAG1
Entrez GeneID
5324Gene Name
PLAG1
Gene Alias
PSA, SGPA
Gene Description
pleiomorphic adenoma gene 1
Gene Ontology
HyperlinkGene Summary
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Pleomorphic adenoma gene 1
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Interactome
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Disease
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Publication Reference
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Prognostic factors in the myoepithelial-like spindle cell type of metaplastic breast cancer.
Leo F, Bartels S, Magel L, Framke T, Busche G, Jonigk D, Christgen M, Lehmann U, Kreipe H.
Virchows Archiv 2016 Aug; 469(2):191.
Application：FISH, Human, Metaplastic breast cancer.
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Prognostic factors in the myoepithelial-like spindle cell type of metaplastic breast cancer.
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