MMP2 monoclonal antibody, clone 2C1
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Specifications
Product Description
Mouse monoclonal antibody raised against recombinant MMP2.
Immunogen
Recombinant protein corresponding to human MMP2.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to pro and active MMP2.
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
ELISA (1 ug/mL)
Western Blot (2-5 ug/mL)
Immunohistochemistry (Frozen sections) (5 ug/mL)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of MMP2 using MMP2 monoclonal antibody, clone 2C1 (Cat # MAB2334).
Lane 1 : Human recombinant MMP2 protein.
2 : Schwann cell culture medium.Immunohistochemistry (Frozen sections)
Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP2
Entrez GeneID
4313Protein Accession#
P08253Gene Name
MMP2
Gene Alias
CLG4, CLG4A, MMP-II, MONA, TBE-1
Gene Description
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
collagenase type IV-A|matrix metalloproteinase 2|matrix metalloproteinase-II|neutrophil gelatinase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve.
Ferguson TA, Muir D.
Molecular and Cellular Neurosciences 2000 Aug; 16(2):157.
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Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan.
Zuo J, Ferguson TA, Hernandez YJ, Stetler-Stevenson WG, Muir D.
The Journal of Neuroscience 1998 Jul; 18(14):5203.
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Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression.
Muir D.
Clinical & Experimental Metastasis 1995 Jul; 13(4):303.
Application:ELISA, WB-Ce, Rat, D6P2T cells, NF1 cells, Schwann cells.
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MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve.
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