HLA-DQB1 MaxPab mouse polyclonal antibody (B01)
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Specifications
Product Description
Mouse polyclonal antibody raised against a full-length human HLA-DQB1 protein.
Immunogen
HLA-DQB1 (AAH12106, 1 a.a. ~ 261 a.a) full-length human protein.
Sequence
MSWKKALRIPGGLRVATVTLMLAMLSTPVAEGRDSPEDFVYQFKGMCYFTNGTERVRLVTRYIYNREEYARFDSDVGVYRAVTPLGPPAAEYWNSQKEVLERTRAELDTVCRHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETTGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQNPIIVEWRAQSESAQSKMLSGIGGFVLGLIFLGLGLIIHHRSQKGLLH
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (75); Rat (75)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Flow Cytometry
FACS analysis of negative control 293 cells (Black) and HLA-DQB1 expressing 293 cells (Green) using HLA-DQB1 purified MaxPab mouse polyclonal antibody.Western Blot (Tissue lysate)
HLA-DQB1 MaxPab polyclonal antibody. Western Blot analysis of HLA-DQB1 expression in human pancreas.Western Blot (Transfected lysate)
Western Blot analysis of HLA-DQB1 expression in transfected 293T cell line (H00003119-T01) by HLA-DQB1 MaxPab polyclonal antibody.
Lane 1: HLA-DQB1 transfected lysate(28.71 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — HLA-DQB1
Entrez GeneID
3119GeneBank Accession#
BC012106Protein Accession#
AAH12106Gene Name
HLA-DQB1
Gene Alias
CELIAC1, HLA-DQB, IDDM1
Gene Description
major histocompatibility complex, class II, DQ beta 1
Gene Ontology
HyperlinkGene Summary
HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq
Other Designations
MHC DQ beta|MHC class II DQ beta chain|MHC class II HLA-DQ beta glycoprotein|MHC class II antigen DQB1|MHC class II antigen HLA-DQ-beta-1|MHC class2 antigen|OTTHUMP00000178570|lymphocyte antigen|major histocompatibility complex class II beta
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Interactomes
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Pathways
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Diseases
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