TRIM21 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TRIM21.
Immunogen
A synthetic peptide corresponding to human TRIM21.
Sequence
CPLNIGSQGSTDY
Host
Goat
Theoretical MW (kDa)
54.2
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TRIM21
Entrez GeneID
6737Protein Accession#
NP_003132.2Gene Name
TRIM21
Gene Alias
RNF81, RO52, SSA, SSA1
Gene Description
tripartite motif-containing 21
Omim ID
109092Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq
Other Designations
Sicca syndrome antigen A|Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)|tripartite motif protein 21
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Interactome
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Pathway
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Disease
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Publication Reference
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52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.
Chan EK, Di Donato F, Hamel JC, Tseng CE, Buyon JP.
The Journal of Experimental Medicine 1995 Oct; 182(4):983.
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52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.
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