AGER polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AGER.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human AGER.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse lung tissue lysate (35 ug/lane) with AGER polyclonal antibody (Cat # PAB4295).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with AGER polyclonal antibody (Cat # PAB4295) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .Enzyme-linked Immunoabsorbent Assay
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Gene Info — AGER
Entrez GeneID
177Protein Accession#
NP_001127;Q15109Gene Name
AGER
Gene Alias
MGC22357, RAGE
Gene Description
advanced glycosylation end product-specific receptor
Omim ID
600214Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000029155|OTTHUMP00000029156|advanced glycosylation end product-specific receptor RAGE3|advanced glycosylation end product-specific receptor variant sRAGE1|advanced glycosylation end product-specific receptor variant sRAGE2|receptor for advanced
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Interactomes
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Diseases
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Publication Reference
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Tissue-specific expression patterns of the RAGE receptor and its soluble forms--a result of regulated alternative splicing?
Schlueter C, Hauke S, Flohr AM, Rogalla P, Bullerdiek J.
Biochimica et Biophysica Acta 2003 Oct; 1630(1):1.
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Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products.
Shanmugam N, Kim YS, Lanting L, Natarajan R.
The Journal of Biological Chemistry 2003 Sep; 278(37):34834.
Application:Pretreated, Recombinant protein.
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Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer.
Kuniyasu H, Chihara Y, Takahashi T.
Oncology Reports 2003 Mar; 10(2):445.
Application:IHC-P, Human, Human colorectal cancer.
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Tissue-specific expression patterns of the RAGE receptor and its soluble forms--a result of regulated alternative splicing?
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