ROCK2 (phospho T249) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ROCK2.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding T249 of human ROCK2.
Sequence
CDTAV
Host
Rabbit
Theoretical MW (kDa)
165
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes ~165 KDa of human ROCK2 at a phosphorylation site of Thr249. It does not react to non-phosphorylated protein.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ROCK2
Entrez GeneID
9475Gene Name
ROCK2
Gene Alias
KIAA0619
Gene Description
Rho-associated, coiled-coil containing protein kinase 2
Omim ID
604002Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq
Other Designations
OTTHUMP00000195104
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Interactome
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Pathway
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Disease
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Publication Reference
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Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin.
Vahebi S, Kobayashi T, Warren CM, de Tombe PP, Solaro RJ.
Circulation Research 2005 Mar; 96(7):740.
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Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin.
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