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NTRK1/NTRK2/NTRK3 monoclonal antibody, clone HHH-14 

  • Catalog # : MAB20811
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of human NTRK1/NTRK2/NTRK3.
  • Immunogen:
  • A synthetic peptide corresponding to human NTRK1/NTRK2/NTRK3.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunocytochemistry (1:50-1:200)
    Immunofluorescence (1:50-1:200)
    Immunohistochemistry (1:50-1:200)
    Western Blot (1:1000-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunocytochemistry
  • Immunofluorescence
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Immunocytochemistry
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 4914
  • Protein Accession#:
  • P04629;Q16620;Q16288
  • Gene Name:
  • NTRK1
  • Gene Alias:
  • DKFZp781I14186,MTC,TRK,TRK1,TRKA,p140-TrkA
  • Gene Description:
  • neurotrophic tyrosine kinase, receptor, type 1
  • Gene Summary:
  • This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000038736,Oncogene TRK,high affinity nerve growth factor receptor,tyrosine kinase receptor A
  • Gene Information
  • Entrez GeneID:
  • 4915
  • Protein Accession#:
  • P04629;Q16620;Q16288
  • Gene Name:
  • NTRK2
  • Gene Alias:
  • GP145-TrkB,TRKB
  • Gene Description:
  • neurotrophic tyrosine kinase, receptor, type 2
  • Gene Summary:
  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • BDNF/NT-3 growth factors receptor,OTTHUMP00000021573,OTTHUMP00000021574,OTTHUMP00000021575,OTTHUMP00000021576,OTTHUMP00000021577,tyrosine kinase receptor B
  • Gene Information
  • Entrez GeneID:
  • 4916
  • Protein Accession#:
  • P04629;Q16620;Q16288
  • Gene Name:
  • NTRK3
  • Gene Alias:
  • TRKC,gp145(trkC)
  • Gene Description:
  • neurotrophic tyrosine kinase, receptor, type 3
  • Gene Summary:
  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. [provided by RefSeq
  • Other Designations:
  • ETS related protein-neurotrophic receptor tyrosine kinase fusion protein,ETV6-NTRK3 fusion,NT-3 growth factor receptor,OTTHUMP00000192915,neurotrophin 3 receptor,tyrosine kinase receptor C
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