NTRK1/NTRK2/NTRK3 monoclonal antibody, clone HHH-14
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More Files
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human NTRK1/NTRK2/NTRK3.
Immunogen
A synthetic peptide corresponding to human NTRK1/NTRK2/NTRK3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:200)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunocytochemistry
Immunofluorescence
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Gene Info — NTRK1
Entrez GeneID
4914Protein Accession#
P04629;Q16620;Q16288Gene Name
NTRK1
Gene Alias
DKFZp781I14186, MTC, TRK, TRK1, TRKA, p140-TrkA
Gene Description
neurotrophic tyrosine kinase, receptor, type 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
Other Designations
OTTHUMP00000038736|Oncogene TRK|high affinity nerve growth factor receptor|tyrosine kinase receptor A
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Gene Info — NTRK2
Entrez GeneID
4915Protein Accession#
P04629;Q16620;Q16288Gene Name
NTRK2
Gene Alias
GP145-TrkB, TRKB
Gene Description
neurotrophic tyrosine kinase, receptor, type 2
Omim ID
600456Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
BDNF/NT-3 growth factors receptor|OTTHUMP00000021573|OTTHUMP00000021574|OTTHUMP00000021575|OTTHUMP00000021576|OTTHUMP00000021577|tyrosine kinase receptor B
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Gene Info — NTRK3
Entrez GeneID
4916Protein Accession#
P04629;Q16620;Q16288Gene Name
NTRK3
Gene Alias
TRKC, gp145(trkC)
Gene Description
neurotrophic tyrosine kinase, receptor, type 3
Omim ID
191316Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. [provided by RefSeq
Other Designations
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein|ETV6-NTRK3 fusion|NT-3 growth factor receptor|OTTHUMP00000192915|neurotrophin 3 receptor|tyrosine kinase receptor C
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Interactome
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Pathway
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Disease
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