Products

Western Blot

Western blot analysis of Lane 1: Hela whole cell lysate (treated with Calyculin A 100 nM/60 mins), Lane 2: Hela whole cell lysate (treated with EGF 100 ng/mL/20 mins), Lane 3: Hela whole cell lysate (not treated), Lane 4: A549 whole cell lysate (treated with Calyculin A 100 nM/60 mins), Lane 5: A549 whole cell lysate (treated with EGF 100 ng/mL/20 mins) and Lane 6: A549 whole cell lysate (not treated) with CDK1/CDK2/CDK3 (phospho T14) recombinant monoclonal antibody, clone 4C12 (Cat # RAB04265).

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

983

Protein Accession#

P06493;P24941;Q00526

Gene Name

CDC2

Gene Alias

CDC28A, CDK1, DKFZp686L20222, MGC111195

Gene Description

cell division cycle 2, G1 to S and G2 to M

Omim ID

116940

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000019660|cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2 protein|cyclin-dependent kinase 1|p34 protein kinase

Entrez GeneID

1017

Protein Accession#

P06493;P24941;Q00526

Gene Name

CDK2

Gene Alias

p33(CDK2)

Gene Description

cyclin-dependent kinase 2

Omim ID

116953

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq

Other Designations

cdc2-related protein kinase|cell devision kinase 2|p33 protein kinase

Entrez GeneID

1018

Protein Accession#

P06493;P24941;Q00526

Gene Name

CDK3

Gene Alias

-

Gene Description

cyclin-dependent kinase 3

Omim ID

123828

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq

Other Designations

-