CSTB recombinant monoclonal antibody, clone R02-7D7
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CSTB.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human CSTB.
Theoretical MW (kDa)
Calculated MW: 11 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4, (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of CystatinB in Hela, A549, HL-60 lysates using CystatinB antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded Human tonsil using CystatinB antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. -
Gene Info — CSTB
Entrez GeneID
1476Protein Accession#
P04080Gene Name
CSTB
Gene Alias
CST6, EPM1, PME, STFB
Gene Description
cystatin B (stefin B)
Gene Ontology
HyperlinkGene Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq
Other Designations
CPI-B|cystatin B|liver thiol proteinase inhibitor|stefin B
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Interactome
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Disease
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