CSTB polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
CSTB polyclonal antibody (Cat # PAB6498) (0.1 ug/mL) staining of human lungs (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CSTB.
Immunogen
A synthetic peptide corresponding to C terminus of human CSTB.
Sequence
C-QTNKAKHDELTYF
Host
Goat
Theoretical MW (kDa)
11.1
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CSTB polyclonal antibody (Cat # PAB6498) (0.1 ug/mL) staining of human lungs (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CSTB
Entrez GeneID
1476Protein Accession#
NP_000091Gene Name
CSTB
Gene Alias
CST6, EPM1, PME, STFB
Gene Description
cystatin B (stefin B)
Gene Ontology
HyperlinkGene Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq
Other Designations
CPI-B|cystatin B|liver thiol proteinase inhibitor|stefin B
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Interactome
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Disease
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Publication Reference
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Cloning a synthetic gene for human stefin B and its expression in E. coli.
Jerala R, Trstenjak M, Lenarcic B, Turk V.
FEBS Letters 1988 Oct; 239(1):41.
Application：WB-Re, Recombinant proteins.
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Cloning a synthetic gene for human stefin B and its expression in E. coli.
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