STAT1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial synthetic peptide of human STAT1.
Immunogen
A synthetic peptide corresponding to amino acids 364-378 of human STAT1.
Sequence
FDKDVNERNTVKGFR
Host
Rabbit
Reactivity
Human, Mouse, Rabbit, Rat
Form
Lyophilized
Purification
Immunogen affinity purification
Isotype
IgG
Recommend Usage
Western Blot (0.1-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.2 mg Na2HPO4, 0.9 mg NaCl (0.05 mg Thimerosal, 0.05 mg sodium azide, 5 mg BSA).
Storage Instruction
Store at -20°C.
After reconstitution with 0.2 mL of distilled water and concentration will be 500 ug/mL, store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and Thimerosol: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of human colon cancer lysate. Using STAT1 polyclonal antibody (Cat # PAB8012) . -
Gene Info — STAT1
Entrez GeneID
6772Protein Accession#
P42224Gene Name
STAT1
Gene Alias
DKFZp686B04100, ISGF-3, STAT91
Gene Description
signal transducer and activator of transcription 1, 91kDa
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000165047|signal transducer and activator of transcription 1|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
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Interactome
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Pathway
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Disease
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Publication Reference
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Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease.
Chapgier A, Boisson-Dupuis S, Jouanguy E, Vogt G, Feinberg J, Prochnicka-Chalufour A, Casrouge A, Yang K, Soudais C, Fieschi C, Santos OF, Bustamante J, Picard C, de Beaucoudrey L, Emile JF, Arkwright PD, Schreiber RD, Rolinck-Werninghaus C, Rosen-Wolff A, Magdorf K, Roesler J, Casanova JL.
PLoS Genetics 2006 Aug; 2(8):e131.
Application:WB, Human, Human B cells, fibrosarcoma cell line 2C4.
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Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.
Xiao L, Naganawa T, Obugunde E, Gronowicz G, Ornitz DM, Coffin JD, Hurley MM.
The Journal of Biological Chemistry 2004 Jun; 279(26):27743.
Application:WB, Mouse, Marrow stromal cells.
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STATs: signal transducers and activators of transcription.
Ihle JN.
Cell 1996 Feb; 84(3):331.
Application:IP, WB-Ce, WB-Tr, Human, Mammalian cells.
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Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease.
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