STAT1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of STAT1 in whole cell lysates from HeLa (H), Jurkat (J), A-431 (A), K-562 (K), and NIH/3T3 (N) cells, with STAT1 polyclonal antibody (Cat # PAB12820) at 1 ug/mL .
Immunocytochemistry
Immunocytochemistry of STAT1 in HeLa cells with STAT1 polyclonal antibody (Cat # PAB12820) at 10 ug/mL .
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STAT1.
Immunogen
A synthetic peptide corresponding to C-terminus of human STAT1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
The sequences differ from the murine corresponding sequences by four amino acids. No reaction to the 84 KDa STfrom1a. A 91 KDa band can be detected.
Form
Liquid
Recommend Usage
Western Blot (1:1000-1:2000)
Immunoprecipitation (2-4 ug)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of STAT1 in whole cell lysates from HeLa (H), Jurkat (J), A-431 (A), K-562 (K), and NIH/3T3 (N) cells, with STAT1 polyclonal antibody (Cat # PAB12820) at 1 ug/mL .Immunocytochemistry
Immunocytochemistry of STAT1 in HeLa cells with STAT1 polyclonal antibody (Cat # PAB12820) at 10 ug/mL .Immunoprecipitation
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Gene Info — STAT1
Entrez GeneID
6772Protein Accession#
NP_009330Gene Name
STAT1
Gene Alias
DKFZp686B04100, ISGF-3, STAT91
Gene Description
signal transducer and activator of transcription 1, 91kDa
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000165047|signal transducer and activator of transcription 1|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Jaks and STATs: biological implications.
Leonard WJ, O'Shea JJ.
Annual Review of Immunology 1998 Apr; 16:293.
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STATs and gene regulation.
Darnell JE Jr.
Science 1997 Sep; 277(5332):1630.
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Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.
Schindler C, Darnell JE Jr.
Annual Review of Biochemistry 1995 Jan; 64:621.
Application：WB-Ce, WB-Tr, Human, Mammalian cells.
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Jaks and STATs: biological implications.
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