The cell lysate derived from MCF-7 was immuno-precipitated by MTOR polyclonal antibody (Cat # PAB12715), resolved onto 7.5% SDS-PAGE, transferred onto NC membrane, then immuno-blotted by MTOR polyclonal antibody (Cat # PAB12715) at 1 : 500. An immunoreactive band around ~290 kDa was observed (lane 1). Lane 2 is a negative control.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq
FK506 binding protein 12-rapamycin associated protein 1,FK506 binding protein 12-rapamycin associated protein 2,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP-rapamycin associated protein,FKBP12-rapamycin complex-associated protein 1