IL2RA monoclonal antibody, clone TP1/6
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Specification
Product Description
Mouse monoclonal antibody raised against native IL2RA.
Immunogen
PHA activated human T cells.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b
Recommend Usage
Flow Cytometry (20 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 1% BSA, pH 7.2 (0.09% sodium azide).
Storage Instruction
Store in the dark at 4°C. Avoid prolonged exposure to light.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Flow Cytometry
Flow Cytometry using human peripheral blood cells (1 ug/106 cells).
FACSCalibur (Becton Dickinson, San Jose, CA) flow cytometer, using Cell Quest acquisition software and PAINT-A-GATE. PRO, analysis software. -
Gene Info — IL2RA
Entrez GeneID
3559Gene Name
IL2RA
Gene Alias
CD25, IDDM10, IL2R, TCGFR
Gene Description
interleukin 2 receptor, alpha
Gene Ontology
HyperlinkGene Summary
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. [provided by RefSeq
Other Designations
Interleukin-2 receptor|OTTHUMP00000019030|OTTHUMP00000044870|interleukin 2 receptor, alpha chain
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Interactome
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Pathway
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Disease
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Publication Reference
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Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells.
Chung IY, Dong HF, Zhang X, Hassanein NM, Howard OM, Oppenheim JJ, Chen X.
Cellular Immunology 2004 Nov; 232:57.
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Characterization of the human receptor for T-cell growth factor.
Leonard WJ, Depper JM, Robb RJ, Waldmann TA, Greene WC.
PNAS 1983 Nov; 80(22):6957.
Application:Func, IA, IP, WB-Re, Human, HUT-102B2, Jurkat cells, PBMCs, Purified proteins.
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A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.
Uchiyama T, Broder S, Waldmann TA.
Journal of Immunology 1981 Apr; 126(4):1393.
Application:Func, Human, Human T cells CTC16 cells.
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Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells.
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