IL2RA/B/G monoclonal antibody, clone NR-72
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Specification
Product Description
Mouse monoclonal antibody raised against native IL2RA/B/G.
Immunogen
Native from Con-A activated human PBL T cells.
Host
Mouse
Reactivity
Human
Specificity
React with human IL2 receptor. Chain specificity was not determined.
Form
Lyophilized
Isotype
IgG
Quality Control Testing
Antibody Reactive Against PBL T cells.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL2RA
Entrez GeneID
3559Gene Name
IL2RA
Gene Alias
CD25, IDDM10, IL2R, TCGFR
Gene Description
interleukin 2 receptor, alpha
Gene Ontology
HyperlinkGene Summary
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. [provided by RefSeq
Other Designations
Interleukin-2 receptor|OTTHUMP00000019030|OTTHUMP00000044870|interleukin 2 receptor, alpha chain
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Gene Info — IL2RB
Entrez GeneID
3560Gene Name
IL2RB
Gene Alias
CD122, P70-75
Gene Description
interleukin 2 receptor, beta
Omim ID
146710Gene Ontology
HyperlinkGene Summary
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq
Other Designations
CD122 antigen|OTTHUMP00000028799|high affinity IL-2 receptor beta subunit|interleukin 2 receptor beta
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Gene Info — IL2RG
Entrez GeneID
3561Gene Name
IL2RG
Gene Alias
CD132, IMD4, SCIDX, SCIDX1
Gene Description
interleukin 2 receptor, gamma (severe combined immunodeficiency)
Gene Ontology
HyperlinkGene Summary
The interleukin 2 (IL2) receptor gamma chain (IL2RG), an important signalling component of many interleukin receptors (IL2,IL4,IL7,IL9, and IL15), is thus referred to as the common gamma chain. Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID). [provided by RefSeq
Other Designations
common cytokine receptor gamma chain|interleukin 2 receptor gamma chain|interleukin 2 receptor, gamma
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Interactome
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Pathway
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Disease
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