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IL2RA/B/G monoclonal antibody, clone NR-72

  • Catalog # : MAB1350
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native IL2RA/B/G.
  • Immunogen:
  • Native from Con-A activated human PBL T cells.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • React with human IL2 receptor. Chain specificity was not determined.
  • Form:
  • Lyophilized
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody Reactive Against PBL T cells.
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with deionized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 3559
  • Gene Name:
  • IL2RA
  • Gene Alias:
  • Gene Description:
  • interleukin 2 receptor, alpha
  • Gene Summary:
  • The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. [provided by RefSeq
  • Other Designations:
  • Interleukin-2 receptor,OTTHUMP00000019030,OTTHUMP00000044870,interleukin 2 receptor, alpha chain
  • Gene Information
  • Entrez GeneID:
  • 3560
  • Gene Name:
  • IL2RB
  • Gene Alias:
  • CD122,P70-75
  • Gene Description:
  • interleukin 2 receptor, beta
  • Gene Summary:
  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq
  • Other Designations:
  • CD122 antigen,OTTHUMP00000028799,high affinity IL-2 receptor beta subunit,interleukin 2 receptor beta
  • Gene Information
  • Entrez GeneID:
  • 3561
  • Gene Name:
  • IL2RG
  • Gene Alias:
  • Gene Description:
  • interleukin 2 receptor, gamma (severe combined immunodeficiency)
  • Gene Summary:
  • The interleukin 2 (IL2) receptor gamma chain (IL2RG), an important signalling component of many interleukin receptors (IL2,IL4,IL7,IL9, and IL15), is thus referred to as the common gamma chain. Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID). [provided by RefSeq
  • Other Designations:
  • common cytokine receptor gamma chain,interleukin 2 receptor gamma chain,interleukin 2 receptor, gamma
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