CCR5 monoclonal antibody, clone T21/8
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with CCR5 monoclonal antibody, clone T21/8 (Cat # MAB12618) at 20 ug/mL working concentration.
Flow Cytometry
Flow cytometric analysis of human peripheral blood cells with CCR5 monoclonal antibody, clone T21/8 (Cat # MAB12618) (colored histogram) and an isotype control mouse IgG1, kappa (open histogram) followed by biotin-conjugated anti-mouse IgG secondary antibody and PE-conjugated streptavidin.
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Specification
Product Description
Mouse monoclonal antibody raised against human CCR5.
Immunogen
Human CCR5
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Flow Cytometry
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL)
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In aqueous buffer (Stabilizer, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with CCR5 monoclonal antibody, clone T21/8 (Cat # MAB12618) at 20 ug/mL working concentration.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Flow cytometric analysis of human peripheral blood cells with CCR5 monoclonal antibody, clone T21/8 (Cat # MAB12618) (colored histogram) and an isotype control mouse IgG1, kappa (open histogram) followed by biotin-conjugated anti-mouse IgG secondary antibody and PE-conjugated streptavidin. -
Gene Info — CCR5
Entrez GeneID
1234Gene Name
CCR5
Gene Alias
CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Gene Description
chemokine (C-C motif) receptor 5
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
C-C chemokine receptor 5|C-C chemokine receptor type 5|CCR5 chemokine receptor|chemokine (C-C) receptor 5|chemokine receptor CCR5|chemr13
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Interactome
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Pathway
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Disease
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