CCR5 monoclonal antibody, clone 12D1
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More Files
- More Functions
Immunohistochemistry (Frozen sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human Stomach tissue.
Immunofluorescence
Immunofluorescence staining of PFA-fixed HeLa cells with Cat# MAB21156 ; followed by goat anti-mouse IgG conjugated to CF488 (green).
Flow Cytometry
Flow cytometric analysis of MCF-7 cells with Cat# MAB21156; followed by goat anti-mouse IgG-CF488 (Blue) and Isotype Control (Red).
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Specification
Product Description
Mouse monoclonal antibody raised against human CCR5.
Immunogen
Native purified human CCR5.
Host
Mouse
Theoretical MW (kDa)
45
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Flow Cytometry (1-2 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Frozen sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Frozen sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human Stomach tissue.Immunofluorescence
Immunofluorescence staining of PFA-fixed HeLa cells with Cat# MAB21156 ; followed by goat anti-mouse IgG conjugated to CF488 (green).Flow Cytometry
Flow cytometric analysis of MCF-7 cells with Cat# MAB21156; followed by goat anti-mouse IgG-CF488 (Blue) and Isotype Control (Red). -
Gene Info — CCR5
Entrez GeneID
1234Protein Accession#
P51681Gene Name
CCR5
Gene Alias
CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Gene Description
chemokine (C-C motif) receptor 5
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
C-C chemokine receptor 5|C-C chemokine receptor type 5|CCR5 chemokine receptor|chemokine (C-C) receptor 5|chemokine receptor CCR5|chemr13
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Interactome
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Pathway
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Disease
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