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Actin (muscle specific) monoclonal antibody, clone HHF35

  • Catalog # : MAB11331
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against muscle-specific ACTA1.
  • Immunogen:
  • SDS extract of human myocardium.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Rabbit
  • Form:
  • Liquid
  • Purification:
  • Protein A/G affinity chromatography
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (0.5-1 ug/million cells)
    Immunofluorescence (0.5-1 ug/mL)
    Immunohistochemistry (0.25-0.5 ug/mL for 30 min at RT)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.05% BSA, 0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical staining of human leiomyosarcoma with Actin (muscle specific) monoclonal antibody, clone HHF35 (Cat # MAB11331) at 0.25-0.5 ug/mL, for 30 min at RT.
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 58
  • Gene Name:
  • ACTA1
  • Gene Alias:
  • ACTA,ASMA,CFTD,CFTD1,CFTDM,MPFD,NEM1,NEM2,NEM3
  • Gene Description:
  • actin, alpha 1, skeletal muscle
  • Gene Summary:
  • The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000036123,alpha skeletal muscle actin
  • Gene Information
  • Entrez GeneID:
  • 59
  • Gene Name:
  • ACTA2
  • Gene Alias:
  • AAT6,ACTSA
  • Gene Description:
  • actin, alpha 2, smooth muscle, aorta
  • Gene Summary:
  • The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000020042,alpha 2 actin,alpha-cardiac actin,growth-inhibiting gene 46
  • Gene Information
  • Entrez GeneID:
  • 70
  • Gene Name:
  • ACTC1
  • Gene Alias:
  • ACTC,CMD1R,CMH11
  • Gene Description:
  • actin, alpha, cardiac muscle 1
  • Gene Summary:
  • Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq
  • Other Designations:
  • cardiac muscle alpha actin 1
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