Western blot analysis of HeLa cell lysate (each 30 ug) was resolved by SDS - PAGE , transferred to PVDF membrane and probed with HSPB1 monoclonal antibody , clone 2A5 (1 : 1000) (Cat # MAB1091). Proteins were visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system.
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq
OTTHUMP00000024846,estrogen-regulated 24 kDa protein,heat shock 27kD protein 1,heat shock protein beta-1,stress-responsive protein 27