MAPK10 monoclonal antibody, clone 10E4A4
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis using MAPK10 monoclonal antibody, clone 10E4A4 (Cat # MAB10598) against NIH/3T3 (1) and SKN-SH (2) cell lysate.
Immunofluorescence
Immunofluorescence staining of methanol-fixed A-431 (upper) and HeLa (bottom) cells showing cytoplasmic and membrane localization.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant MAPK10.
Immunogen
Recombinant protein corresponding to amino acids 28-233 of human MAPK10.
Host
Mouse
Theoretical MW (kDa)
53
Reactivity
Human, Mouse
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunofluorescence (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using MAPK10 monoclonal antibody, clone 10E4A4 (Cat # MAB10598) against NIH/3T3 (1) and SKN-SH (2) cell lysate.Immunofluorescence
Immunofluorescence staining of methanol-fixed A-431 (upper) and HeLa (bottom) cells showing cytoplasmic and membrane localization.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAPK10
Entrez GeneID
5602Gene Name
MAPK10
Gene Alias
FLJ12099, FLJ33785, JNK3, JNK3A, MGC50974, PRKM10, p493F12, p54bSAPK
Gene Description
mitogen-activated protein kinase 10
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
JNK3 alpha protein kinase|MAP kinase|OTTHUMP00000161180|OTTHUMP00000161182|OTTHUMP00000161183|c-Jun N-terminal kinase 3|c-Jun kinase 3|stress activated protein kinase JNK3|stress activated protein kinase beta
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Interactome
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Pathway
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Disease
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