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Last updated: 2016/12/4
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PSEN2 monoclonal antibody, clone 198C679.2.

  • Catalog # : MAB0101
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of PSEN2.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids of human PSEN2.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgM
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In tissue culture supernatant (0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis for PSEN2. Using PSEN2 monoclonal antibody, clone 198C679.2. (Cat # MAB0101) at 1 : 500 against 30 ug/lane of HL-60 cell lysate. A protein band of approximate molecular weight of 55 KDa was detected.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
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  • Gene Information
  • Entrez GeneID:
  • 5664
  • Gene Name:
  • PSEN2
  • Gene Alias:
  • AD3L,AD4,PS2,STM2
  • Gene Description:
  • presenilin 2 (Alzheimer disease 4)
  • Gene Summary:
  • Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq
  • Other Designations:
  • Alzheimer's disease 3-like,OTTHUMP00000035671,presenilin 2
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