PSEN2 monoclonal antibody, clone 198C679.2.
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis for PSEN2. Using PSEN2 monoclonal antibody, clone 198C679.2. (Cat # MAB0101) at 1 : 500 against 30 ug/lane of HL-60 cell lysate. A protein band of approximate molecular weight of 55 KDa was detected.
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of PSEN2.
Immunogen
A synthetic peptide corresponding to amino acids of human PSEN2.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgM
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In tissue culture supernatant (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis for PSEN2. Using PSEN2 monoclonal antibody, clone 198C679.2. (Cat # MAB0101) at 1 : 500 against 30 ug/lane of HL-60 cell lysate. A protein band of approximate molecular weight of 55 KDa was detected. -
Gene Info — PSEN2
Entrez GeneID
5664Gene Name
PSEN2
Gene Alias
AD3L, AD4, PS2, STM2
Gene Description
presenilin 2 (Alzheimer disease 4)
Gene Ontology
HyperlinkGene Summary
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq
Other Designations
Alzheimer's disease 3-like|OTTHUMP00000035671|presenilin 2
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Interactome
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Pathway
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Disease
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