PSEN2 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of tissue and whole cell extracts with PSEN2 polyclonal antibody (Cat # PAB19096).
Lane 1 : rat brain.
Lane 2 : MCF-7. Lane 3 : HeLa. Lnae 4 : SMMC. Lane 5 : CEM.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of rat brain tissue with PSEN2 polyclonal antibody (Cat # PAB19096).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PSEN2.
Immunogen
A synthetic peptide corresponding to internal region of human PSEN2.
Host
Rabbit
Reactivity
Human, Rat
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
Immunohistochemistry (Frozen sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of tissue and whole cell extracts with PSEN2 polyclonal antibody (Cat # PAB19096).
Lane 1 : rat brain.
Lane 2 : MCF-7. Lane 3 : HeLa. Lnae 4 : SMMC. Lane 5 : CEM.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of rat brain tissue with PSEN2 polyclonal antibody (Cat # PAB19096).Immunohistochemistry (Frozen sections)
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Gene Info — PSEN2
Entrez GeneID
5664Gene Name
PSEN2
Gene Alias
AD3L, AD4, PS2, STM2
Gene Description
presenilin 2 (Alzheimer disease 4)
Gene Ontology
HyperlinkGene Summary
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq
Other Designations
Alzheimer's disease 3-like|OTTHUMP00000035671|presenilin 2
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Interactome
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Pathway
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Disease
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