PSEN2 recombinant monoclonal antibody, clone R02-5B8
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More Files
- More Functions
Western Blot
Western blot analysis of Presenilin 2 in rat Brain, C6, 3T3, Hela lysates using human Presenilin 2 recombinant monoclonal antibody, clone R02-5B8 (Cat # RAB01737).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against synthetic peptide of human Presenilin 2.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human Presenilin 2
Theoretical MW (kDa)
Calculated MW: 50 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation (1:20)
Western Blot (1:500-1:1,000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Presenilin 2 in rat Brain, C6, 3T3, Hela lysates using human Presenilin 2 recombinant monoclonal antibody, clone R02-5B8 (Cat # RAB01737).Immunoprecipitation
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Gene Info — PSEN2
Entrez GeneID
5664Protein Accession#
P49810Gene Name
PSEN2
Gene Alias
AD3L, AD4, PS2, STM2
Gene Description
presenilin 2 (Alzheimer disease 4)
Gene Ontology
HyperlinkGene Summary
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq
Other Designations
Alzheimer's disease 3-like|OTTHUMP00000035671|presenilin 2
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Interactome
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Pathway
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Disease
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