BCL2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of BCL2.
Immunogen
A synthetic peptide corresponding to human BCL2.
Sequence
AGRTGYDNREIVMKYC
Host
Goat
Theoretical MW (kDa)
26.3, 22.2
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_000624, NP_000648).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
BCL2 polyclonal antibody (Cat # PAB6666) staining (1 ug/mL) of human lymph node lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BCL2
Entrez GeneID
596Protein Accession#
NP_000624;NP_000648Gene Name
BCL2
Gene Alias
Bcl-2
Gene Description
B-cell CLL/lymphoma 2
Omim ID
151430Gene Ontology
HyperlinkGene Summary
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq
Other Designations
B-cell lymphoma protein 2|OTTHUMP00000163680
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Interactome
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Pathway
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Disease
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Publication Reference
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Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro.
Yu XQ, Xue CC, Zhou ZW, Li CG, Zhou SF.
Phytotherapy Research: PTR 2008 Jun; 22(6):846.
Application:WB-Ti, Rat, Rat cortical neurons.
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In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice).
Yu XQ, Xue CC, Zhou ZW, Li CG, Du YM, Liang J, Zhou SF.
Life Sciences 2007 Nov; 82(1-2):68.
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Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro.
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