EIF4EBP1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of EIF4EBP1.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human EIF4EBP1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (2.5-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of EIF4EBP1 in NIH/3T3 cell lysate with EIF4EBP1 polyclonal antibody (Cat # PAB12947) at (A) 2.5, (B) 5 and (C) 10 ug/mL .Immunocytochemistry
Immunocytochemistry of EIF4EBP1 in NIH/3T3 cells with EIF4EBP1 polyclonal antibody (Cat # PAB12947) at 2 ug/mL . -
Gene Info — EIF4EBP1
Entrez GeneID
1978Protein Accession#
NP_004086Gene Name
EIF4EBP1
Gene Alias
4E-BP1, 4EBP1, BP-1, MGC4316, PHAS-I
Gene Description
eukaryotic translation initiation factor 4E binding protein 1
Omim ID
602223Gene Ontology
HyperlinkGene Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq
Other Designations
eIF4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Integration of growth factor and nutrient signaling: implications for cancer biology.
Shamji AF, Nghiem P, Schreiber SL.
Molecular Cell 2003 Aug; 12(2):271.
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4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle.
Shah OJ, Anthony JC, Kimball SR, Jefferson LS.
American Journal of Physiology. Endocrinology and Metabolism 2000 Oct; 279(4):E715.
Application:WB, Human, Mouse , Skeletal muscles.
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Integration of growth factor and nutrient signaling: implications for cancer biology.
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