EIF4EBP1 recombinant monoclonal antibody, clone 4EB1T37T46-A5 (APC)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of Jurkat cells treated with LY294002 and unstained as negative control (blue) or treated with LY294002 and stained (red) or treated with TPA and stained (green) using phospho-4E-BP1 (Thr37/Thr46) antibody, 4EB1T37T46-A5 APC conjugate.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human EIF4EBP1.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr37/46 of human phospho 4E-BP1
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Conjugation Note
APC
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.09% Sodium azide, 0.2% BSA
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Jurkat cells treated with LY294002 and unstained as negative control (blue) or treated with LY294002 and stained (red) or treated with TPA and stained (green) using phospho-4E-BP1 (Thr37/Thr46) antibody, 4EB1T37T46-A5 APC conjugate. -
Gene Info — EIF4EBP1
Entrez GeneID
1978Protein Accession#
Q13541Gene Name
EIF4EBP1
Gene Alias
4E-BP1, 4EBP1, BP-1, MGC4316, PHAS-I
Gene Description
eukaryotic translation initiation factor 4E binding protein 1
Omim ID
602223Gene Ontology
HyperlinkGene Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq
Other Designations
eIF4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
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Interactome
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Pathway
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Disease
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