Formalin-fixed paraffin-embedded section of a human prostate cancer tissue array stained for BCL2 expression. Using BCL2 polyclonal antibody (Cat # PAB0236) at 1 : 2000. Hematoxylin-eosin counterstain.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq