BCL2 monoclonal antibody, clone 124
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of BCL2.
Immunogen
A synthetic peptide corresponding to amino acids 41-54 of human BCL2.
Sequence
GAAPAPGIFSSQPG
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G affinity chromatography
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (0.25-0.5 ug/mL for 30 min at RT)
Immunoprecipitation (0.5-1 ug/500 ug protein lysate)
Western Blot (0.25-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunohistochemical staining of human tonsil with BCL2 monoclonal antibody, clone 124 (Cat # MAB11332) at 0.25-0.5 ug/mL, for 30 min at RT.Immunofluorescence
Immunoprecipitation
Flow Cytometry
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Gene Info — BCL2
Entrez GeneID
596Gene Name
BCL2
Gene Alias
Bcl-2
Gene Description
B-cell CLL/lymphoma 2
Omim ID
151430Gene Ontology
HyperlinkGene Summary
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq
Other Designations
B-cell lymphoma protein 2|OTTHUMP00000163680
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Interactome
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Pathway
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Disease
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Publication Reference
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MicroRNAs as Potential Regulators of GSK-3β in Renal Cell Carcinoma.
Masaki Murata, Vladimir Bilim, Yuko Shirono, Akira Kazama, Kaede Hiruma, Masayuki Tasaki, Yoshihiko Tomita.
Current Issues in Molecular Biology 2023 Sep; 45(9):7432.
Application:WB, Human, A549, Caki-1 cells.
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Long-term expression pattern of melanocyte markers in light- and dark-pigmented dermo-epidermal cultured human skin substitutes.
Biedermann T, Klar AS, Bottcher-Haberzeth S, Michalczyk T, Schiestl C, Reichmann E, Meuli M.
Pediatric Surgery International 2015 Jan; 31(1):69.
Application:IF, Human, Skin.
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MicroRNAs as Potential Regulators of GSK-3β in Renal Cell Carcinoma.
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