Immunohistochemical analysis of paraffin-embedded human colon cancer tissues (upper) and human larynx cancer tissues (bottom) using JMJD2A monoclonal antibody, clone 5H1 (Cat # MAB10708) with DAB staining.
Immunofluorescence analysis of NTERA-2 cells using JMJD2A monoclonal antibody, clone 5H1 (Cat # MAB10708) (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq
OTTHUMP00000008810,jumonji C domain-containing histone demethylase 3A