RB1 recombinant monoclonal antibody, clone RbS807S811-D9
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More Files
- More Functions
Western Blot
Western blot analysis of NIH3T3 cell extract untreated or treated with 20% FBS using Phospho-Rb (Ser807/Ser811) antibody RbS807S811-D9 at 0.1 ug/mL.
Flow Cytometry
Flow cytometric analysis of U937 cells untreated and unstained as negative control (blue) or untreated and stained (green) or treated with lambda phosphatase and stained (red) using Phospho-Rb (Ser807/811) antibody RBS807S811-D9. at 1 ug/mL.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human RB1.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser807/Ser811 of human phospho Rb
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Recommend Usage
Flow Cytometry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.02% Sodium azide, 50% Glycerol, 0.1% BSA
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of NIH3T3 cell extract untreated or treated with 20% FBS using Phospho-Rb (Ser807/Ser811) antibody RbS807S811-D9 at 0.1 ug/mL.Flow Cytometry
Flow cytometric analysis of U937 cells untreated and unstained as negative control (blue) or untreated and stained (green) or treated with lambda phosphatase and stained (red) using Phospho-Rb (Ser807/811) antibody RBS807S811-D9. at 1 ug/mL. -
Gene Info — RB1
Entrez GeneID
5925Protein Accession#
P06400Gene Name
RB1
Gene Alias
OSRC, RB, p105-Rb, pRb, pp110
Gene Description
retinoblastoma 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018397|retinoblastoma suspectibility protein|retinoblastoma-associated protein
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Interactome
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Pathway
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Disease
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