ADRBK1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ADRBK1.
Immunogen
A synthetic peptide corresponding to human ADRBK1.
Sequence
C-RDAYREAQQLVQR
Host
Goat
Theoretical MW (kDa)
79.7
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
ADRBK1 polyclonal antibody (Cat # PAB6974) (0.3 ug/mL) staining of Daudi cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADRBK1
Entrez GeneID
156Protein Accession#
NP_001610.1Gene Name
ADRBK1
Gene Alias
BARK1, BETA-ARK1, FLJ16718, GRK2
Gene Description
adrenergic, beta, receptor kinase 1
Omim ID
109635Gene Ontology
HyperlinkGene Summary
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq
Other Designations
beta adrenergic receptor kinase 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure.
Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, Trimarco B, Koch WJ.
European Heart Journal. 2005 Sep; 26(17):1752.
Application:Func, IP-WB, Human, Cardiac.
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Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure.
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