ADRBK1 monoclonal antibody, clone 5D5
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More Files
- More Functions
Immunohistochemistry
ADRBK1 monoclonal antibody, clone 5D5 (Cat # MAB2373) (green) and neurofilament NF-M (red) staining, in rat cortex, showing mostly large pyramidal neurons. Photo courtesy of Dr. Gerry Shaw, University of Florida.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant ADRBK1.
Immunogen
Recombinant protein corresponding to human ADRBK1.
Host
Mouse
Reactivity
Bovine, Human, Rat
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Immunohistochemistry (1:100)
Western Blot (1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In tissue culture supernatant
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
ADRBK1 monoclonal antibody, clone 5D5 (Cat # MAB2373) (green) and neurofilament NF-M (red) staining, in rat cortex, showing mostly large pyramidal neurons. Photo courtesy of Dr. Gerry Shaw, University of Florida.Immunocytochemistry
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Gene Info — ADRBK1
Entrez GeneID
156Protein Accession#
P25098Gene Name
ADRBK1
Gene Alias
BARK1, BETA-ARK1, FLJ16718, GRK2
Gene Description
adrenergic, beta, receptor kinase 1
Omim ID
109635Gene Ontology
HyperlinkGene Summary
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq
Other Designations
beta adrenergic receptor kinase 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
Harding VB, Jones LR, Lefkowitz RJ, Koch WJ, Rockman HA.
PNAS 2001 May; 98(10):5809.
Application：WB-Ti, Mouse, Mouse hearts.
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G protein-coupled receptor kinases.
Pitcher JA, Freedman NJ, Lefkowitz RJ.
Annual Review of Biochemistry 1998 Jul; 67:653.
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Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.
Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ.
PNAS 1986 May; 83(9):2797.
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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
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