PARK7 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of PARK7 polyclonal antibody (Cat # PAB4487) in mouse brain,kidney,liver tissue lysates and NIH-3T3, HeLa cell line lysates (35 ug/lane). PARK7 (arrow) was detected using the purified PARK7 polyclonal antibody (Cat # PAB4487).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PARK7.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PARK7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of PARK7 polyclonal antibody (Cat # PAB4487) in mouse brain,kidney,liver tissue lysates and NIH-3T3, HeLa cell line lysates (35 ug/lane). PARK7 (arrow) was detected using the purified PARK7 polyclonal antibody (Cat # PAB4487).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PARK7
Entrez GeneID
11315Protein Accession#
NP_009193;Q99497Gene Name
PARK7
Gene Alias
DJ-1, DJ1, FLJ27376, FLJ34360, FLJ92274
Gene Description
Parkinson disease (autosomal recessive, early onset) 7
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000001348|OTTHUMP00000001349|OTTHUMP00000001350|OTTHUMP00000001351|Parkinson disease protein 7|oncogene DJ1|protein DJ-1
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Interactome
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Disease
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Publication Reference
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DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3.
Shinbo Y, Taira T, Niki T, Iguchi-Ariga SM, Ariga H.
International Journal of Oncology 2005 Mar; 26(3):641.
Application：IF, WB-Tr, Human, HEK 293T, HeLa, NCI-H1299 cells.
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DJ-1, a novel regulator of the tumor suppressor PTEN.
Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC, DeLuca C, Liepa J, Zhou L, Snow B, Binari RC, Manoukian AS, Bray MR, Liu FF, Tsao MS, Mak TW.
Cancer Cell 2005 Mar; 7(3):263.
Application：IHC-P, WB, Human, A-549 cells, Human breast cancer.
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Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients.
Takahashi-Niki K, Niki T, Taira T, Iguchi-Ariga SM, Ariga H.
Biochemical and Biophysical Research Communications 2004 Jul; 320(2):389.
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DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3.
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