SPTA1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human bone marrow with SPTA1 polyclonal antibody (Cat # PAB30985) shows strong cytoplasmic positivity in subsets of bone marrow poietic cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human SPTA1.
Immunogen
Recombinant protein corresponding to human SPTA1.
Sequence
HQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVEL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human bone marrow with SPTA1 polyclonal antibody (Cat # PAB30985) shows strong cytoplasmic positivity in subsets of bone marrow poietic cells. -
Gene Info — SPTA1
Entrez GeneID
6708Protein Accession#
P02549Gene Name
SPTA1
Gene Alias
EL2, SPTA
Gene Description
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Gene Ontology
HyperlinkGene Summary
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq
Other Designations
OTTHUMP00000021115|alpha-I spectrin|erythrocyte alpha-spectrin|erythroid alpha-spectrin|spectrin alpha chain, erythrocyte|spectrin, alpha, erythrocytic 1
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Interactome
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Disease
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